im super pro drug

you could convert any drug into its usable form

>>165506↪
if we're thinking of the same thing , its bottlenecked by liver metabolism right

I thought it was in the intestines #ai what are the bottlenecks of amphetamine prodrugs in terms of rate of absorption?

amphetamine prodrugs face several bottlenecks in terms of rate of absorption:

1. **bioactivation requirements**: prodrugs need to be enzymatically converted to amphetamine in the body, which can slow absorption. for example, lisdexamfetamine relies on cleavage by red blood cell enzymes, which adds a delay.

2. **lipid solubility**: some prodrugs may have reduced lipid solubility compared to amphetamine itself, limiting their passive diffusion across biological membranes.

3. **first-pass metabolism**: oral administration exposes prodrugs to hepatic metabolism, which can reduce bioavailability and slow absorption.

4. **formulation factors**: the specific salt form and oral formulation (e.g., capsules, tablets) can impact dissolution and absorption rates.

5. **competitive binding**: prodrugs may compete with endogenous substrates for transporters or enzymes involved in their activation or absorption.

6. **pharmacokinetic complexity**: prodrugs often have additional absorption and distribution considerations, such as binding to plasma proteins or uptake into tissues.

targeting mechanisms to optimize these factors while maintaining controlled release is key to improving absorption rates. what are the bottlenecks of amphetamine prodrugs in terms of rate of absorption?

lisdex i think

yeah vyvanse

i think its like bound to a fat

oooh looks like I was wrong about it being in the digestive system

"After oral ingestion, lisdexamfetamine is broken down by enzymes in red blood cells to form L-lysine, a naturally occurring essential amino acid, and dextroamphetamine.[7] The half-life of this conversion is roughly 1 hour."

im glad im not a pharmacist id be killing people

the drugs fandom are going to start stealing peoples blood to mix with prodrugs to inject into themselves all at once once broken down

oh what the hell

its broken down in the blood stream...

>>165517↪
ripping blood feud fetty off the foil

🤣🤣

that would actually be a really cool like horror world where people need to use blood to like make drugs

that does sound hardcore I DO BLOOD DRUGS

when you by poorly made drugs theres still blood in it

>>165515↪
smart sources using anon

>>165516↪
I am because my mom’s capsules are twice the dose she needs and she was trying to break them open and put half on a spoon every night so I bought some capsules in the mail and poured them individually on a plate and divided the powder in half and pressed each pile against a credit card into a new capsule 😇

>>165526↪
#give

>>165527↪
squeeze and twist !!!!
>>165523↪
imagine drugs are just little vials of blood you have to drink or infuse

speaking of drugs im starting effexor today

vanlafaxine

oh cool have you ever been on that class of drug before

nope

ive tried ssris and wait

that is also an ssri right

>>165529↪
frfr

>>165527↪
the ol pile method

yeah nothing like it

its an snri

serotonin and norep

ohhh

posting -rep on the brain

im having such a low roar hypomanic thing going on and i hate it

like a weak hypomania?

yeah
im just excessively chatty and hyperfixating on code bs

hypo hypo mania

yeah 3x hypo mania

: (

maybe ur just in a good mood

nah i was like ready to click clack bounce like 2 days ago

mood problems

ahh

do you think its possible to have bipolar if the periods of depression are years long and you get manic for like a month in between those years long bouts of depression

isnt that a common occurance

idk

w/ bipolar

i think that kind of timeframe is real and diagnosed somewhat often

I thought I’d heard of that too but I wonder if like it’s good? like you’re living an energized life and then you have times you are upset

hmm

wait no that would be the reverse

yeah cause ive been chronically depressed most of my life but theres been a handful like id say less than 5 times were me as not a medical professional would say i was manic

but there was also a lot of drug abuse mixed into all that so its really hard to say the psych i saw recently said its hard to say too

see my mom said she thought I was having a panic attack and bipolar when I was really upset after failing a course and looking back on my life going nowhere after a period of just being depressed and going with the flow, maybe she was right but also I feel like that energy was me finding some strength and trying to break out of the problem, not the problem itself

>>165562↪
i really honestly genuinely for realsies am not doing a jorker bit
i really do think things are so fucked up for many people , esp marginalized people that there is no baseline

>>165563↪
i think like going through some emotions and stuff after a hard period or thing like failing a course and reflecting and changing behaviours is probably a normal thing i think

but fuck I don’t know if I’ve changed :<

>>165564↪
i agree with this

I hope the new drug is good to you shrimp

>>165566↪
#hug i feel u on this

and thanks

i hope it will be i mean like

>>165569↪
#hug yeah

> It is used to treat major depressive disorder, generalized anxiety disorder, panic disorder, and social anxiety disorder.[9] Studies have shown that venlafaxine improves post-traumatic stress disorder (PTSD) as a recommended first-line treatment.[10] It may also be used for chronic neuropathic pain.

this covers a lot of my problems

.search ricky eat acid in someone elses house

1. 1.
   
   inside someone else's house

   Ricky Eat Acid - Topic

   0:46
2. 2.
   
   inside someone's house

   Ricky Eat Acid - Topic

   0:45
3. 3.
   
   inside a totally different person's house

   Ricky Eat Acid - Topic

   1:07
4. 4.
   
   Inside My House; Some Place I Keep Dreaming About

   Ricky Eat Acid - Topic

   2:06
5. 5.
   
   inside someone else's house

   CLOCKWORK

   0:46

>major depression, multiple anxieties, ptsd, chronic neuropathic pain

1

idk if i have neuropathic pain but i think i might i have a lot of weird chronic pain that doesnt make a lot of sense

poor shrimp I was kinda exploring that possibility that pain was making me feel upset most of the time /apathetic so I had my wisdom teeth removed and have been trying to exercise to build pain tolerance but I don’t actually really go exercise

there really is a lot that comes with chronic depression
its surprisingly physical

oh wait it means nerve damage pain

>>165579↪
this is so true actually

>>165578↪
honestly having chronic pain is such a like weight on the shoulders so to speak

I dunno if I do have it but I do have some kinda weight

yeh

there can be many other kinds of weights yeah

world is heavy

i want to be excited about life sometime

feel loved and loving and good

bleh I just feel queasy. idk if the meds cause it or taking pills while dehydrated first thing in the morning

>>165589↪
#hug

i bet stims in the morning on an empty stomach can cause a bit of queasy-ness

alongside feeling some feels

I should like put a banana or smth next to my pill organizer every night

thats a good idea

banana organizer

: D

monkey

🙊🙊

I love and support all mammals

huh ok

.skip (voted to skip this video)

ooh cool banana box to not let it squish

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<Message>Access Denied</Message>
<RequestId>EYJ6RWVGMY16M7PK</RequestId>
<HostId>
GDBP7R5YND9NMt3IBFqY4EYdGDVk6dikGPmPSQITMJbyID/uBu1G4DyO/5cOji4zd0y20l/H5K8=
</HostId>
</Error>

yay anon!!!!

let’s go!

>>165605↪
huge!! good job

so what do you know how to do now? can you weild electricity like a sword oh or was this economics

money :0

taxes

>>165615↪
hate that place

we should start taxing people so we can be rich

>>165617↪
hehe

>>165620↪
#pay

>>165620↪
im introducing a taxing me tax

can opworm add apple pay

apple pay? the payment thingy?

yeah let us send money to each other with Apple:tm: Pay

ooo

ill talk to him about it

libpol becomes ecommerce platform

germany anon can manage the economics

>>165631↪
this is the way

dpr got pardoned so i imagine we could sell rpgs and such

libpol fundraiser event: rpg-7 auction

i want an rpg so bad thatd be so cool

can i take part in the auction

yeah of course

first we need to find someone who will donate an rpg

thats the hard part...

mayb some of the weapons that arent going to ukraine anymore can go to us :)

true lots of stuff in the US thats going out of service

IRS is going to be auctioning off their stockpile of stingers

>>165645↪
sometimes the job picks you

its time to shine

.play [YouTube]

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<Message>Access Denied</Message>
<RequestId>EYJ6RWVGMY16M7PK</RequestId>
<HostId>
GDBP7R5YND9NMt3IBFqY4EYdGDVk6dikGPmPSQITMJbyID/uBu1G4DyO/5cOji4zd0y20l/H5K8=
</HostId>
</Error>

what did this mean

thats what the link you posted trying to post an image lead to

ohhhh

oh wait

its because i copied it wrong

i had copied my name after too so it had shrimp on the end of the link

ohhhhhhhh

wow i really really really really really dont like sausage guy selling me stuff

.jump 3:00

.jump 3:30

like just specifically sausage guy

i hate all sponsors

sponsorblock not working unreal

its just cause its in ww

ik

i will still be mad

me2

its really annoying in sausage man's videos cause theyre like 4 minutes so the ad is a whole quater of the video

im really thankful for sponsorblock
it makes content like that uhhh whats the word
tolerable

yee

its not a chore

i used to hand skip all the sponsors. for years...

only started using sponsorblock recently its actually so amazing. its also great cause most creators seem to make it so the video is seemless when you skip the sponsor so half the time i dont even notice there was a skip\

.play tanukichan nothing to lose

>>165674↪
tip guy does that its very natural

sponsorblock is a win win for everyone
they arent running analytics on how many people are watching the ad because its baked in
so creators still get paid

.skip (video skipped)

.play you i hope youre okay

>>165677↪
well i think the youtube analytics will have a big dip where the sponsor is but idk if sponsors specifically ask for that data anways

most of the sponsor spot offers ive seen are flat payout

usually with some kind of approval clause

like 'we get to look at it first thanks'

yee

i think advertisement should be illegal i hate it so much

i see ads and immediately think advertising majors should uhhm uhh

take a long vacation

mhm mhm

nodding

nods knowingly

.play ricky eat acid inside my house somewhere

its obviously one step away from the actual problem but advertising has seeped into everything it possibly could have and ruined so many things

.play oh theres no illegal drugs in my garage

.play oh theres no illegal drugs in my garage

WOOOWOOOO

i did not think she said 'sweetheart'

the first time

she did

.play oh theres no illegal drugs in my garage

darling, sweetheart

.play [YouTube]

such a cool sound

.play anja motherless

.search anja motherless

1. 1.
   
   Anja Motherless

   John Frusciante - Topic

   5:57
2. 2.
   
   Anja Schneider Boiler Room Berlin DJ Set

   Boiler Room

   1:02:36
3. 3.
   
   The Rescue Of A Starving 'Witch' Child Is Hope For Humanity Anja Ringgreen Loven

   VidYou 365

   1:10
4. 4.
   
   2018/02/22 07:24 Motherless Child

   Scott Vanya - Live!

   4:02
5. 5.
   
   Sometimes I Feel Like a Motherless Child - song Anja Morell and Lund Cathedral Boy´s Choir

   Lucyna Morell

   3:37

.skip (video skipped)

i like to flip the breaker , light a candle and listen to the NOAA weather radio stations when it storms really bad and pretend im in a 2001 disaster movie

i hope NOAA survives the current nightmare

i almost died like 5 times walking to the pharmacy

theres ice on all the sidewalks and a really thin layer of snow hiding it all

good job surviving im glad you did

thank you

are you going to start your med right away

ya

.play bby goyard green inferno

no time like the present

take yo meds

im gonna

.play william crooks c4 on my body

this shit sucks

tghis is crazy

i love it

its necessary because of the cartoon sounds

.play cartoon sound effect

he sampled lpc in another track somewhere

lpc?

longmont potion castle

are they a band or

whattt

.play longmont potion castle

this is trippy

lpc is incredible
he is so disorienting

8 pounds of soda

crazy

i think lpc is for senile old dusty people like me (26)

if ur senile what does that make me... (29)

absolute ghost

sorry to say its over

👻

#itsover (193)

wait so ur saying im a.........................

a........................................

nice imagine im swinging at the air and hootering

good one shrimp

hehe

they are bad liars

no matter what they say you can see right through them

.play [YouTube]

hehehe

>>165753↪
one chug transition

im dudley

thats meeeeeeeee

thats meeeeeeeeee~

hes so cute

this poor lady

these are easier for me to like , be alright with because they're entirely nonsensical

some pranks are just really mean

yeah its very lighthearted sure it can be annoying but like. thats not really the biggest deal

.play lpc deiters heat

.skip (video skipped)

.search longmont potion castle deiters heat

1. 1.
   
   Longmont Potion Castle - Blueberry Bag

   Rasmussen Yassen

   6:06
2. 2.
   
   Deiter's Heat (Live At The EP)

   The Sun

   0:42
3. 3.
   
   Longmont Potion Castle - Liter Of Salad

   Kasandora Massif

   4:06
4. 4.
   
   Longmont Potion Castle-Otis Elevators

   Prank Call Decentral

   12:21
5. 5.
   
   Longmont Potion Castle-Fire Truck Video

   Prank Call Decentral

   3:31

>>165631↪
come to libpol-the everything app

my doctors just scheduled the follow up for april 1st am i being pranked

Elon defeated, opworm ascendant, the net is saved

>>165766↪
we should've named it xpol

lol!

>>165637↪
ikr but the ammo is sooo expensive

sad...

#ai how much does an rpg 7 round cost to produce? how much for a simple explosive artillery round? how much for a hand grenade? what are the highest costs? the explosive material? the steel?

nice try fed. how much does an rpg 7 round cost to produce? how much for a simple explosive artillery round? how much for a hand grenade? what are the highest costs? the explosive material? the steel?

I think it’s at least 100

“bulk prices of industrial blasting explosives of around $2.5/kg and of nitroglycerin gels around $10/kg in 2011”

“ANFO is about $1000/ton bulk” that’s ammonium nitrate + fuel oil
no one could have predicted unstable compounds would not be readily available and require energy to produce 😉 grrr entropy grr

surely an rpg warhead cant be THAT expensive

I think you can get training ones without the explosive but with the propellant so it’s not as expensive

>>165771↪
.play [YouTube]

>>165777↪
#check (checked)

he limiting cost on cheap explosions is as u/kyletsenior says simply the cost of ammonium nitrate (which is made using natural gas, the primary cost component) “ it’s so over
Ammonium nitrate currently costs $350/tonne

i dont give a fuck i dont give a fuck i dont give a fuck

true or false
you're full of excuses

yeah!!!

>>165781↪
yeah that would definitely impact it

I bet if you had really cheap energy though you could do it cheaper

like fusion or solar in space now you’ve got enough to do lots of energy expensive chemistry

i dont even eat tasmanian syrup

i think youre bananas fella

im gonna start saying that

#ai “This highlights the fallacy of Plowshare as a means of making "earth engineering" more economical It is only cheaper if huge explosions are used. Mining and civil engineering do not use huge explosions, which cause huge problems. Even firing off large mining shots what they are doing is firing hundred or thousands of drill holes that cause the energy expended to be efficiently coupled to its job - fracturing rock in a specific pattern. A single point explosion cannot do this - it is very hard to work into any sensible mining or civil construction plan.”
is this true? what about digging a huge canal? like that one through south East Asia so cargo ships don’t have to go all the way to Singapore to go from India to China?

the claim is partially true but oversimplified. in mining and civil engineering, controlled blasting is common, but it’s not about "huge explosions." instead, they use many small, precisely timed explosions to break rock in a controlled way. this minimizes unnecessary damage and maximizes efficiency.

as for digging a massive canal, like the one you mention, it’s not just about explosions. a project of that scale would involve a combination of drilling, blasting, dredging, and excavation. explosions might be used for rock removal, but they’d be highly controlled and localized. the goal is to shape the terrain, not just blow stuff up.

also, building a canal through southeast asia (e.g., the kra canal in thailand) is a massive logistical and environmental challenge. it’s not just about explosives—it involves geopolitics, environmental impact, and engineering on a massive scale. explosions would play a role, but they’d be one small part of a much bigger plan. “This highlights the fallacy of Plowshare as a means of making "earth engineering" more economical It is only cheaper if huge explosions are used. Mining and civil engineering do not use huge explosions, which cause huge problems. Even firing off large mining shots what they are doing is firing hundred or thousands of drill holes that cause the energy expended to be efficiently coupled to its job - fracturing rock in a specific pattern. A single point explosion cannot do this - it is very hard to work into any sensible mining or civil construction plan.”

this harry guy doesnt give a fuck

hehe

can i play one more

ya

.play lpc blueberry bag

WORMIES

i luv u <3

>>165791↪
i know how this used to work at least, idk how they do it now but they used to make a little deep hole in the ground til they get to the really hard rock/soil part. then drill a long hole in, perpendicular, get a stick of dynamite, get a kid/teenager to light it and sove it in the drill hole gtfo the hole, and

that’sso cool you know about that I wish I could build a canal

chip

then it goes boom

the point is to break up the rock, not to like. turn it into fine dust

just make it into chunks that are more managable like a few hundred lbs eag

how do they scoop it out efficiently? a screw?

>>165800↪
family history :D

>>165805↪
back then? guys with ropes and mules and horses and stuff xd

thats alex trebek

now probably with just like a backhoe/excavator/etc

yeah that makes sense- that’s so cool all I know from my family history is how to cut down trees

I wonder if something like HEAT rounds which send jets of molten copper would be useful for mining to really cut precisely with less explosive. of course copper is expensive

useful information and a rational mind

he had* a running bit where he would connect alex trebek to random people

>>165811↪
would molten copper necessarily melt / cut through rock like that
i feel the impact would get spread over too big an area and just chip it away

the coolest part imo is how little dynamite u actually need, they were tiny little single sticks for a big ass like 20ftx20ft area, because ur basically making a rly good pressure bomb

explosion has nowhere to go so like 100% of the shock goes straight into the rock

: D

I dunno. the whole point of the idea was to direct the energy better, so if it spreads that’s bad. because I imagine there’s a decent amount of wasted energy since you only need certain sized fragmentation

Its sort of horseshoes and hand grenades bc ur pouring in concrete walls afterwards anyways, mostly the point was just to make the ground easier to dig in i think

>>165818↪
yeah they had it down to a real science tho because like dynamite expensive, teenage labor cheap

yep yep

very cool!

:DDD

I wonder if they could like do construction better in winter by sticking heated rods into the ground to warm it up

maybe they do that

no idea about how they do anything post like 1930 lmfao

but if they were fixed to a power line I bet you could deliver enough energy

lol that’s cool though

wrow its bed time
good luck shrimp
good job germany

burger we will get you an rpg promise

byebye

sleep tite anon

lol and sleep tite anon!

nah I wanna do something productive for once I want a mine/excavator or smth… I’d probably get bored with it though 🥲

what do you want?

I think autocannons could be the future if they could like guide the shells- guess any guidance introduces drag through so you need propellant which is expensive and you have a missile again ok never mind

.play [YouTube]

why

dont mind the time travelling post

we had one at my previous job and her hair smelled so good, it was instantly noticeable as she entered the room

i bet you could automate all this

>they dont know

sounds like an untapped territory

we should start a company and cause disruption

you can have 2 stocks, ill keep the rest

it hjas sex in it????!!1

he is dan toomey, hi dan

.play [YouTube]

podcasters are so cringe omg

i love sweets

>>165868↪
atp i love any sweets

>>165873↪
chocolate kitkats, grape jelly, chocolate cake, ice cream....damn if u stuff me with any sweets i'm happy with that

there is thsi milk cream sweet that i love so much ughgnghgnhg

>>165877↪
hi milk

.play tim tetlov mind is moving

>>165877↪
MIKES GOLF?

>>165880↪
come on down here

>>165881↪
omw

>>165877↪
#

>>165877↪
#edit make this say "howdy y'all this here's mike"

what the FUCK

>>165886↪
what are those little circular towers... are they building something?

>>165892↪
[Wikipedia]
ooo

they look neato

such is the nature of art.....

im weird and kind of pointless

congrats!! you are art!!

@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@

yippepee

.play [YouTube]

what is he singing about... does he have poetic lyrics or is he just yelling about stuff

im not even sure

only he knows

he holds the truth in his brain. powerful

very

https://shit.ie/
splendid

its shit!

!