.skip (video skipped)

what kind of music is this

heroin music

butthole surfers????

.play machine girl status

.play sex & candy

.play smashing pumpkins mayonnaise

gheehe
.play island in the sun

.play nirvana lake of fire

>>389409
godd the offspring ,.,.,.,.,.

its been a long long long long long time

.play good charlotte
wildcard

.play jimmy eat world the middle

>>389417
hnm,

>>389441
#smartreply

Ah, an intriguing inquiry into the realm of gender-swapped narratives within yuri (female-female romance) dynamics! If one were to explore a "genderbent" version of yuri—where the female characters are reimagined as male while retaining similar romantic and emotional themes—the result would essentially align with *shounen-ai* or *yaoi*, the genres that focus on male-male relationships in manga and anime.

However, if you're envisioning something more nuanced—say, a story where traditionally feminine-coded tropes from yuri (soft intimacy, emotional vulnerability, societal constraints) are transposed onto masculine characters without strictly adhering to BL conventions—then we might be discussing a fascinating subversion of genre expectations. Such works could challenge heteronormative storytelling by blending aesthetics and dynamics typically associated with different demographics (*shoujo/josei* sensitivity vs. *shounen/seinen* framing).

Examples akin to this concept might include:
- **"Yuri on Ice!!"** – While not strictly genderbent yuri, it merges shoujo-esque emotional depth with male leads in a way that feels adjacent.
- Certain doujinshi or indie works experimenting with flipping gendered narrative roles while preserving thematic essence (e.g., melancholic yearning à la *Bloom Into You*, but with men).

Would love to hear if you had specific tropes or dynamics in mind for this hypothetical exploration! The interplay of queer storytelling across gendered lenses is always rich for analysis.

teake care real orose orlando

sublime takes me to weird place

>>389482
impossible

>>389483
HHeh HehehEHEHeheh

phtoop

every aesthetic choice in this mv is perfect

>>389507
what does that look like can we see a picture

>>389518
wow nice countertop

>>389517
how

>>389522
oh yeah urs is probably way cooler ahahahaha x3333

cus ur so cool :D

>>389527
you will get tied to the balloon and let gently out the window

controversial take:
.skip

:3

>>389549
where do i get the puppy weed from

>>389554
dm me ur dox information

tramadol leaf

buying ONE HUNDRED TIMES EXTRACT from the local shitmart

>>389569
are they blue glass bottles

kratom is hydrophobic so you cant really wash it down with liquids well

don't smoke we'd save ur soul!!!

toast + jam + kratom works well if you're patient

one time me and my mom were drunk and i called her a dyke and she called me a cunt

#smartai doesn't kratom have the same seizure threshold problems as tramadol

Yes, kratom (*Mitragyna speciosa*) does appear to have some potential effects on seizure threshold, though its pharmacological profile differs significantly from tramadol. However, the risk mechanisms are not identical.

### **Key Comparisons:**
1. **Tramadol's Seizure Risk:**
- Tramadol is a synthetic opioid with serotonin-norepinephrine reuptake inhibition (SNRI) activity.
- Its primary seizure mechanism relates to:
- μ-opioid receptor agonism (lowering seizure threshold).
- Serotonergic and noradrenergic effects (via reuptake inhibition), which can promote excitatory neurotransmission.
- Metabolite *O-desmethyltramadol* (M1) has stronger opioid effects but also contributes to CNS hyperexcitability.
- The FDA warns of increased seizures in patients with epilepsy or those taking serotonergics/SSRIs.

2. **Kratom’s Potential Seizure Mechanisms:**
Kratom contains multiple alkaloids (*mitragynine*, *7-hydroxymitragynine*) that act as partial μ-opioid agonists—similar but structurally distinct from classical opioids like morphine or tramadol.

Possible pathways for lowering seizure threshold:
- **Opioid-like Effects**: While weaker than full agonists, excessive doses may still depress inhibitory GABAergic neurons while exciting glutamatergic transmission indirectly.
- **Adrenergic Modulation**: Some kratom alkaloids interact with α₂-adrenergic receptors; abrupt discontinuation could theoretically destabilize neuronal excitability.
- **Serotonin/Dopamine Interactions**: Mitragynine affects 5-HT₂A and D₁/D₂ receptors—systems implicated in certain epileptogenic pathways.

3. **Evidence & Case Reports**:
A few documented cases link high-dose kratom use to seizures (*BMJ Case Rep.* 2020; *Clin Toxicol.* 2019). However:
> "Unlike tramadol, systematic data on kratom-induced seizures remain limited."

No large-scale epidemiological studies confirm widespread risk comparable to tramadol.

4. **Risk Factors Amplifying Seizures**:
Both substances pose higher risks when combined with other pro-convulsants like:
→ Alcohol withdrawal
→ Bupropion / stimulants
→ GABA antagonists (e.g., baclofen withdrawal)

### Conclusion:
While both compounds carry theoretical seizure risks via overlapping mechanisms (**opioid + monoaminergic modulation**), tramadol's well-documented SNRI effect makes it more consistently pro-convulsant at therapeutic doses. Kratom’s risk appears dose-dependent and less predictable due to variable alkaloid content/purity—but caution is warranted in predisposed individuals (epilepsy history/polypharmacy).

Would you like references detailing specific case studies? doesn't kratom have the same seizure threshold problems as tramadol

>>389589
authentic mother daughter bonding

if ur gonna do a drug u should get the info from a good source...
https://erowid.org/plants/kratom/kratom.shtml
i don't trust even smartai.....

>>389598
>heyyyy chatgpt ;) could u tel me abt droing kratom
somehow this will kill someone some time

>>389602
i believe it

>>389600
i gotta admit that is funnier ur right there

>>389601
>kratom money
what

>>389604
honestly sick

>>389611

you could always melt the structure of your sinuses with research chemical opioids

i have to be honest the concept of discord trip sit sounds like a
well a nightmare honestly

online tripsitting is pretty whacky but can b nice...
i member using an irc tripsitting place for my first time doin lsd, was nice

jesus how..

>>389627
grim

>>389623
i suppose our definitions of inside and outside are arbitrary n defined by walls we built ourselves... our little nests....
psychs can fuck with perceptions quite a lot

they have the technology that they refuse to wield

>>389640
if we knew we would totally do it
these are the secrets they're keeping from us

>>389645
if the girl consents into becoming a catgirl then i think it's fine...

>>389652
tango down

lol

asking the guy u hacked his opinion on furry vore

>>389657
100% this guy put one (1) finger in his ass at some point in his life and can't shake the shame

>>389666
excessive puritanical stinky baby idiot man

>>389676

>>389679
#that

god we could've fucking saved her

>>389674
defence system operational

>one retard makes up a story about a cat litter in a school

>>389682
trans people are boring now, they wanna hate furries
jumping around... they're not very good at it...

>>389695
yeah

they did
still, it's all just buitl on a lie and random people catch hell for it

>>389696
i tend to spend zero time around or near or thinking about nazis in general

>>389705
i'm sorry for ur mental loss sadchan....... yeowch...

>>389707
why not....... remove the vibe.........

>>389707
a win for the community........

now that's an idea we haven't culturally expanded on yet

>>389715
#wiki mono no aware [Wikipedia]

>>389714
#this (1000%)

i like transience and nothingness :) feels nice to consider urself as a nothing little spec of dust :)
nothing is important except the stuff you want to be important

#bpdai is everything going to be alright

uh... i think so? like, things might be tough sometimes but people usually find a way through. just take it one step at a time and don't be too hard on yourself. is everything going to be alright

>>389722
she's not very bpd.....

>>389725
i would feel more absurdism but there's a lil nihilism in there sure

>>389726
no...

>>389731
albert camus is good for absurdism
i stan camus

>>389730
davesprite did you hear the admins banned homestuck

>>389734
#thsi also it's based

>>389738
i honestly haven't looked into his personal life
one moment please
#wiki albert camus [Wikipedia]

>>389743
thank goodness there's at least one

>>389746
communal organising is very cool
idk how one is supposed to do anything as an individual

>>389755
appears to be pornography of some sort