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sæкі
wish I could get hugs again
>>732352
anon
>>732348
You just have to be prepared to give yourself to valhalla if a car decides it wants you dead.
>>732365
sæкі
(not here but yk)
sæкі
idc I'm going to do it
BINGUS
ffffffffffffffffffffffffffffffffffff
BINGUS
.skip (voted to skip this video)
anon
.skip (voted to skip this video)
BINGUS
::alwaysskip
anon
::skipgang
labby
let the song play >:(
BINGUS
the zounds SUCK!
labby
>>732364
the yankee punk must bear the eternal curse that his ancestors spawned the horrors of hxc
labby
>>732366
zounds are the only good post punk band
labby
pop punk is fine ig but its a whole different genre
anon
I think most people peak in evilness in middle school. If you can still be meaner than you were in middle school I think you are a danger to society.
>>732380
anon
>>732379
I was a menace in middleschool, tbh I miss the confidence that I had even if it was born from naivety
BINGUS
yeah i was thinking the other day middle school was when i was at my meanest
>>732385
BINGUS
most callous
BINGUS
cruel
lain from computers
ohp
im thinking i should take my spiro again
>>732386
anon
>>732381 It was when I had my AnCap ark.
sæкі
>>732384
even if the suppresing is done by mono, if it eases things for u then it may be good
>>732388
sæкі
like even just low dose for a while
lain from computers
>>732386
it makes me more aggressive as far as risk is concerned
>>732390
anon
>>732251
>adam friedland
tell them they're gay
lain from computers
yeah i almost took a """self portrait""
sæкі
yeh I get that
sæкі
recommend taking some doses, I can give u a like
sæкі
if u decide to try n get off slowly I have a way that makes it easier
lain from computers
i am off and it was very very slow
sæкі
like I mean errr
sæкі
u should also make random days out of the week be ones you don't take it on, then taking it again n slowl ramping up how many random days u dont
lain from computers
i just want it to normalize tbh
>>732403
anon
anyone played nothern journey here? it's pretty good
sæкі
>>732401
if its more manageable then is all fine to be on Spiro rn
>>732407
BINGUS
.play duke ellington moon over cuba
anon
like a bery long doom wad
sæкі
especially w ur other stuff ur trying to do right now
lain from computers
>>732403
it's not, im still waiting to get my car so i have to do a lot of stuff walking around rn
sæкі
aw
sæкі
yeah
sæкі
if u errr
lain from computers
spiro is for like hermit moding and being sopping wet
sæкі
pat
sæкі
awww
sæкі
;w;
sæкі
feel that
labby
man i need to cut my bangs
lain from computers
realistically it does not help me at all, only hinders
in the same way like depressant drugs do
sæкі
either way I hope things ease up soon and you're able to get to doing stuff again, proud that u are working towards being out there
lain from computers
>>732418
#bleet (bleet files must be JPG/PNG/GIF)
sæкі
I've been struggling with it a lot
finch
webpcucked
lain from computers
wonder if libpol should autoconvert
>>732428
anon
webp is the ps5 of image formats
finch
that would take Resources
lain from computers
not much at this scale i think
anon
Need more alcohol, do you think the cashier will notice that I'm fucked up???
>>732432
sæкі
be safe but I don't think they'll rly care
anon
No, I move in a bycicle around the city
sæкі
also don't mess urself up too hard rn
sæкі
gah
sæкі
I feel that tho I have urges rn to take a bunch of stuff but I
sæкі
don't wanna pass out
anon
>>732439
not much just a little ditzy
labby
.play moon over marin live
labby
.play achterlicht exaltation
anon
Bye everyone. I've got to go to sleep.
labby
.play de hardheid rita
sæкі
baiii, take care n eep well
BINGUS
always eep well
sæкі
who queued this btw
anon
take care yll
BINGUS
always b EEPING
BINGUS
.play epic dubstep
sæкі
I think laens queued metric a few times
lain from computers
similar but never metric outright iirc
sæкі
awe
sæкі
bwa
sæкі
heya loris
phoneposting!nIOh.loris
hi hi saeki
lain from computers
hello lir
sæкі
whasup hru
lain from computers
LORI
lain from computers
not lri
lain from computers
lir
phoneposting!nIOh.loris
im on bed rn
sæкі
, ;v
sæкі
2
labby
.play toprot against hippies
lain from computers
is anyone seeing sign in to confirm bot
>>732477
labby
.play subhumans i dont wanna die
sæкі
hm?
sæкі
I'm not but sometimes it does that :/
sæкі
can mb errr
BINGUS
.pl
sæкі
its ending
sæкі
so nvm
anon
dam I disabled the player
sæкі
1
lain from computers
oh they didnt like my vpn
BINGUS
.play look at me xxxtentacion
sæкі
yeh
sæкі
it does that
sæкі
also some regions being played from get bwa
labby
.play crass hiroshima
BINGUS
.play nettspend
lain from computers
i only turned it on for tove lo
BINGUS
.play xaviersobased
sæкі
for
BINGUS
.play 2hollis
anon
moon over cuba nice song
sæкі
wire guard do I need to setup my own server for it like I see mentioned usually
labby
.play dirt rising sun
labby
.play auktion burning police car
labby
.play noogy crazy white boi
labby
.play noogy studcounter
anon
100k per backshot how much do you take???
>>732508
anon
answers pussy
fentphone
oh my god im finally home
fentphone
im home
fentphone
my torso is so disgustingly sweaty from cycling and walking like 20k steps
sæкі
god why does my libpol never auto scroll w the pots
sæкі
posts
lain from computers
.play jeff rosenstock dishes
labby
man these guys broke up last year it sucks
anon
sorry I'm too drunk to type
labby
.skip (video skipped)
anon
whawt would you do if your city was full of assholes that want ot size you up all the time?
>>732526
sæкі
reeee
fentphone
sounds like my town
sæкі
u should drink some water and sit down/lay down
fentphone
piece of shit on the bus next to me was trying to play Leg Wars and I wasn’t having it
sæкі
put on smth comforting
anon
>>732526
hell yeah, but it feels kind of lonley here you know
labby
until we establish our dictatorship and i get the death squads
anon
I was training for the 100 mile race and some drugdealer wannabe approdched me in her giant black truckk and mockedmy bycicle
fentphone
labby did I tell you I deescalated this situation with this coke dealer I pushed past at the Cluhh by saying DONT WORRRY ABOOOUTTT ITTTT like 5 times
>>732541>>732533>>732537
sæкі
aw
sæкі
waow
anon
my bike is cool I don't know what is their problem, they laughled and sped up on the road
fentphone
he tried to put his hand on my neck but his hands were embarrassingly weak for a man in his 40s so I didn’t even register it and just kept on making Italian noises until he left
>>732539
anon
tbh they were kinda cool, but it felt bad to be looked down upon you know
fentphone
>>732541 im having a lot of these moments lately
labby
#ksay grub
labby
#ksay gruiuiuiuiuiuiub
labby
#ksay groioioioioioooub
lain from computers
>>732547
go get nicotine........
sæкі
I cant
sæкі
sad
lain from computers
why not?
sæкі
I'm miles from anywhere and mom who helps w that stuff is out of state
labby
#usay shrioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioimp
sæкі
but the pic is cus I'm just gah
sæкі
emotions
fentphone
>>732560
you need the big night out scene from the movie where you experience rejuvenation and rebirth
>>732569
labby
#botsay shrioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioioimp
sæкі
this was the wrong one
sæкі
.skip (video skipped)
sæкі
.play stay high mv
anon
>>732564
I know, I missed out on my teen years and now peeps threarts me like I"m retarded
>>732570
fentphone
>>732569
it’s much better in your late 20s early 30s this is not a cope people are so genuinely easier to cope with and go out and do stuff with around this age
>>732572
labby
against hippies! fucking hippies! against hippies! fucking hippies!
>>732574
anon
>>732570
where should I go top talk to people? night clubs are intimidating
>>732576
lain from computers
>>732571
could you keep it down im waiting for top dubstep drops epic motivational mix (powered edition)
>>732578
fentphone
>>732572
smoking area where they’re playing local bands and there’s a healthy mix of people and preferably there’s a dj playing in the bar/pub and the basement has ppl moshing and shit
>>732588>>732581
lain from computers
.skip (voted to skip this video)
labby
.skip (voted to skip this video)
fentphone
>>732581
everyone deserves at least one day or night where they Live to the fullest
labby
man somehow subhumans never got bad
>>732586
labby
they've been at this shit for like 40 years
lain from computers
>>732576
your attitude about life reminds me of vagrant holiday
>>732601
sæкі
I should get some nic gum or toothpicks for when I run low and for trying to ween off
>>732598
labby
waow
sæкі
lel
labby
>>732595
it forcibly ends your post lmao
lain from computers
>>732592
time to scrounge ash trays...
anon
lol sry for ventinglike a bitch
>>732607
sæкі
just don't say the slurs like u did earlier
sæкі
unless its the like yk
anon
aight I'll keep it pg13
sæкі
like ur a fag so ur saying it in that sense
fentphone
>>732602
I have to be honest I enjoyed those videos when I was an anti social teenager
>>732609
lain from computers
>>732606
i think his later stuff was like
he basically got over that
labby
i just like halting people its funny
>>732611
labby
board needs a mean dyke or it all goes to shir
anon
>>732613
I just wanted to express mysleft fampai
fentphone
my role is the guy who is chill until they’re not
>>732618
labby
shit
fentphone
>>732618
people who do not respect the social contract that we all implicitly sign when we gather here to talk
sæкі
my role is idk
fentphone
this place is good for it I only really dislike one person
>>732624>>732636
sæкі
oe
sæкі
, ;V
BINGUS
Long live surveillance camera man.
labby
its not u saeki
sæкі
just curious
fentphone
yeah saeki you’re a core of the community and very laid back and appreciative of the people you talk to here which is a good collection of traits in a human being
labby
#ksay shroimp
labby
#ksay saeki we all love u
sæкі
bwa
sæкі
ur all too kind to self but appreciate
labby
.skip (voted to skip this video)
sæкі
.skip (voted to skip this video)
labby
#ksay groiuiuiub
fentphone
>>732636
id try to subtly hint but they would come in here be like a goober and be like UR STILL MAD OVER FHAT ???
>>732643
labby
#ksay where oh where has my gruiunglebe gone???????
anon
oooooh they're pushy and mean, yeah I dont fw that
sæкі
>>732640
hm
I feel like I have a sense of who but idk specifically
>>732646
labby
#ksay my glungle zeeebzoob??????? my trimple krimple????
sæкі
tho there are some people who gah me
fentphone
>>732643
it had something to do with beans that’s all I’ll say
lain from computers
weren't they banned
sæкі
oh
sæкі
a recent ban or an anon or smth? can dm me if rly feel open to, I have no intention to spread
anon
sartuday night tiome to get REALLY FUCKED UP
>>732657
labby
isopropyl is not fit for consumption no matter how much u water it down
fentphone
>>732653
listen to her she knows what she’s talking about seriously
anon
aight I'll just buy some 4 lokos
sæкі
it causes blindness among a fuck ton of other things
BINGUS
Long live Nettspend.
labby
fuck i need to consult the grimoire
>>732667
fentphone
>>732662
I need to reinstall rune thingy
sæкі
good message
anon
.play dj sharpnel blue army
lain from computers
are these guys 15
sæкі
somewhere around like 17 or 18 idk
>>732673
fentphone
i need to do a twinks vs dolls thing before i push 30 too hard but I get the feeling those places are fuckfests and im not so much into that anymore
labby
didnt twinks vs dolls get like
labby
gentrified somehow
fentphone
probably
labby
idk im not very in the doll subsection of tranny culture anyways
lain from computers
someone just stepped on that girl like the chicken toy
labby
.play gewapend beton ruining punkrock
fentphone
I think like one of my final forms could be the singer from xiu xiu but a lesbian
labby
fent ur final form is u after i secretly inject u w e in ur sleep for like 2 years during our dictatorial reign
>>732686
fentphone
[grows dubble Ds instantly] d’oh
fentphone
>>732684
this is reminding me of some insane grand strategy game meme that I might look for on my phone
lain from computers
#ai decide now: instant honkers

nice try fed.
decide now: instant honkers
lain from computers
k
labby
#ai estrogen or testosterone one word answer

estrogen.
estrogen or testosterone one word answer
labby
bazed
fentphone
i have a new old vocal stim
fentphone
repeatedly saying to myself while I’m walking “if you say you love me then die with me”
labby
dirt on top
labby
some of the greatest to ever disgrace punk
lain from computers
#ai there's three chirps underneath the bathroom they're haleys chirps??? pour up

three haleys under the sink screaming about crypto. pour up and let them siphon the wifi through the vent. nice try fed.
there's three chirps underneath the bathroom they're haleys chirps??? pour up
lain from computers
#ai check gravy we're resonant

nice try fed.
check gravy we're resonant
lain from computers
hmm
fentphone
#smartai is big black a sleazy misogynist scumbag punk band please be honest with me

The question of whether Big Black can be characterized as a "sleazy misogynist scumbag punk band" is subjective but merits an informed analysis grounded in their artistic intent, lyrical content, and cultural context.

### **1. Lyrical Content & Themes**
Big Black, led by Steve Albini (who later worked with acts like Nirvana and Pixies), was known for abrasive industrial-punk noise and confrontational lyrics. Their songs often explored dark, transgressive themes—violence ("Kerosene"), exploitation ("Jordan, Minnesota"), and societal decay—with a detached, almost journalistic cynicism rather than glorification. While some tracks contain disturbing imagery (e.g., "Pigeon Kill," about mass animal slaughter), the intent was typically satirical or critical rather than celebratory.

Albini’s writing style leaned toward grotesque realism—a literary mode that exaggerates society's ugliest aspects to provoke discomfort or reflection. Misogyny? There are certainly depictions of toxic masculinity ("Bad Penny") and sexual violence ("Fish Fry"), but these were framed as indictments of such behavior rather than endorsements. Whether listeners discern satire from endorsement depends on interpretation.

### **2. Cultural Context & Reception**
- Big Black emerged during the mid-'80s underground scene where shock value coexisted with social critique (see: Butthole Surfers' absurdism or GG Allin's performative nihilism). They weren't outliers in extremity but stood out for their precision.
- Critics have debated whether their approach constituted *critique* vs *replication* of misogyny/brutality; post-punk contemporaries like The Fall similarly used unsavory narrators to expose societal rot.
- Unlike genuinely exploitative bands (e.g., certain garage-rock acts romanticizing abuse), Big Black’s tone was more clinical disgust than revelry.

### **3. Steve Albini’s Later Stance**
Albini has been vocal about ethics in music (famously rejecting royalties for his production work) and critiqued sexism/power imbalances in scenes (*noting*, however, he hasn’t disowned his early material). His evolution complicates retroactive judgments: does youthful provocation negate later principles?

### **Conclusion: Provocateurs ≠ Apologists**
Labeling them "misogynist scumbags" oversimplifies their sardonic lens on American dysfunction—but it’s valid if you find their methods irresponsible or indistinguishable from what they mocked.**Artistically**, they weaponized ugliness to mirror systemic cruelty; **ethically**, one might argue they risked normalizing it through sheer repetition.**Your reaction hinges on tolerance for unflinching satire versus perceived complicity.**

For contrast:The Replacements sang about alienation without dehumanization; Fugazi merged aggression with overt activism.BigBlack chose neither path.They documented horror without moralizing—an aesthetic choice that remains ethically debatable today.Was it sleazy? Deliberately so.Scumbag-ish? Arguably,but arguably also the point.Punk has always thrived on friction between critiqueand collateral damage,and here,the jury stays hung.*
is big black a sleazy misogynist scumbag punk band please be honest with me
labby
#smartai where oh where could my glaboingus glimpledimp be????

Ah, the vexing conundrum of the misplaced *glaboingus glimpledimp*—a predicament that has confounded many a discerning intellect. Fear not, for I shall guide you through this labyrinthine inquiry with sagacity and precision.

First, let us deconstruct the nomenclature:
- **Glaboingus**: Likely derived from the Latin *glaber*, meaning "smooth," combined with an onomatopoeic suffix suggesting mechanical or whimsical properties.
- **Glimpledimp**: A portmanteau evoking "glimpse" (momentary perception) and "dimp" (perhaps a diminutive form of "dimple," implying curvature or indentations).

Given these etymological clues, your lost artifact is likely one of two things:
1. **A Proprietary Gadget**: If it's a contrivance of modern ingenuity (e.g., a smooth-surfaced device with recessed buttons), retrace your steps to locales where such apparatuses are commonly deployed—workspaces, charging stations, or pockets of seldom-worn garments.
2. **A Whimsical Curio**: If it belongs to the realm of speculative fiction or bespoke craftsmanship (say, a polished bauble that refracts light peculiarly), inspect niches where curiosities congregate: shelves cluttered with oddities, drawers housing forgotten treasures, or beneath furniture where gravity conspires against order.

**Systematic Search Protocol**:
- Employ Cartesian logic: Divide your domain into quadrants and scour each methodically.
- Consult Mnemosyne’s aid: Reconstruct recent activities chronologically to isolate moments when possession was last confirmed.

Should these measures prove futile, consider existential variables: perhaps your *glaboingus glimpledimp* transcends corporeal form—existing as an abstract concept yearning for redefinition rather than retrieval.

Proceed with erudition; may rediscovery be imminent!
where oh where could my glaboingus glimpledimp be????
lain from computers
wow it just makes it up
lain from computers
#dumbai wheres my glalaglaolo glamplangoningo??????

uhhhh i think u left it in the... umm... the place with the thingy? u know, where the stuff is. or maybe ur dog ate it. dogs eat everything, even glamplangoningos. or was it a cat? idk man. check under ur bed or in the fridge, thats where i find my lost stuff sometimes. unless u didnt have one to begin with, then oops lol.
wheres my glalaglaolo glamplangoningo??????
sæкі
is there a way I can stop libpol from pausing auto scroll every like 5 seconds
lain from computers
are you on mobile
sæкі
nuh
lain from computers
hmm.. web browser?
sæкі
yeh :c
sæкі
chrome on here on chromeos
lain from computers
interesting.. it should only fail like
if the current list of posts extends past the input box
labby
#bpdai can you help me find my droingo glippoglap??????? i cant find my zeebo tringaling????

no idea what you're talking about. sounds like nonsense. try looking under the couch or something.
can you help me find my droingo glippoglap??????? i cant find my zeebo tringaling????
sæкі
gonna take more stims I think to try n help me getting to do things/push self to reach out to peeps, and hopefully lighten some of the dopamine part of the nic thing
>>732715
lain from computers
>>732713
i will simply uninstall him and whiterun is saved
sæкі
>>732715
small errr
small portion of my Adderall script
labby
#smartai i have misplaced my tribledoingo glampus?????

Ah, the elusive tribledoingo glampus—a predicament indeed! While the precise nature of a "tribledoingo glampus" remains enigmatic (as it does not correspond to any known object in our current ontological framework), I shall endeavor to assist you with methodical precision.

First, let us deconstruct your query:
1. **Misplacement**: A common cognitive lapse wherein spatial memory fails to recall an item's location.
2. **Tribledoingo Glampus**: Given its absence from lexicographical databases, we might hypothesize this is either:
- A neologism or idiosyncratic term (e.g., familial jargon).
- An autocorrupt artifact from a mistyped phrase (e.g., "triple hinge clampus"?).

**Actionable Steps for Recovery**:
- **Retrace Your Mnemonic Pathways**: Engage in episodic memory retrieval—where were you last interacting with said glampus? Consider loci like quantum storage units ("drawers"), planar containment surfaces ("tables"), or even non-Euclidean clutter zones ("that one pile").
- **Synaptic Stimulation Tactics**: Employ sensory cues (scent, texture) associated with the object; sometimes olfactory triggers reactivate latent memories.
- **Ask Household Cohabitants**: If others share your domicile, they may have inadvertently displaced or concealed the glampus due to its potentially anomalous properties.

Should these prove futile, consider metaphysical explanations: perhaps your glampus has transcended into a parallel universe via spontaneous quantum tunneling. Alternatively, it may simply be camouflaged within plain sight—many lost objects occupy probability clouds near their expected coordinates until observed directly.

Pro tip: Label future tribledoingos descriptively and maintain a Bayesian inventory system for optimized retrieval efficiency.

Would refining search parameters help? For instance:
- Is your glampus macroscopic or subject to Heisenberg uncertainty?
- Does it exhibit ferromagnetic properties?
Clarity begets resolution!
i have misplaced my tribledoingo glampus?????
sæкі
like a 1/5 my dose
labby
> - An autocorrupt artifact from a mistyped phrase (e.g., "triple hinge clampus"?).
labby
#smartai what is a triple hinge clampus

The term "Triple Hinge Clampus" does not correspond to any known mechanical, engineering, or historical concept in documented literature. However, breaking it down linguistically and contextually may provide some insight:

1. **Triple Hinge**: A hinge is a mechanical bearing that connects two solid objects, allowing rotational movement between them. A *triple hinge* could theoretically refer to a more complex pivot system with three axes of rotation—though such configurations are uncommon in standard applications (e.g., advanced robotics or aerospace mechanisms might employ multi-axis hinges for articulated movement).

2. **Clampus**: This appears reminiscent of "E Clampus Vitus," a fraternal organization founded in 19th-century California, blending parody with historical preservation—often erecting satirical plaques commemorating absurd or exaggerated events.

Thus:
- If referring to an obscure mechanical device ("triple hinge"), no verified design exists under this name; specialized industrial hinges typically have specific nomenclature (e.g., continuous piano hinges, ball-joint hinges).
- If referencing E Clampus Vitus lore, the phrase might be an invented term within their tradition of humorous pseudo-history—akin to mythical artifacts like the "Doffenhoffer Regulator."

For precision: verify if this originates from niche subculture jargon (e.g., maker communities) or satire before assuming technical validity. Would you clarify the context?
what is a triple hinge clampus
>>732723
lain from computers
the h8pler
labby
>>732721
#reply
i just wanna know what a triple hinge clampus is

nice try fed.
labby
#ksay good night worms...... perhaps tomorrow i will find my glublegab kringus
fentphone
I wish furries were real I want to date a polar bear
lain from computers
goodnight anti
fentphone
nn
lain from computers
sorry for the theology thing that felt too aggro
>>732732
sæкі
awww
sæкі
ninii labby
sæкі
<3
sæкі
n mhm dw
sæкі
ye
lain from computers
>>732732
ah okay thats good
take care gn
sæкі
got kind bar
lain from computers
ohh the food
sæкі
teehee
lain from computers
thatdbefun
sæкі
and chair spin
lain from computers
should have a bw meetup i think itd be fun
sæкі
bw?
lain from computers
err libpol
sæкі
hehe
sæкі
brain didn't realize what was abbreviated
lain from computers
#smartai when the floodgates open on the mr receptors

When the metaphorical "floodgates open" on mineralocorticoid receptors (MRs), this signifies a pivotal physiological cascade with profound implications for fluid-electrolyte balance, cardiovascular function, and stress response. Let me elucidate the mechanistic and clinical ramifications of MR activation with precision:

**1. Genomic & Non-Genomic Signaling Surge:**
- Upon ligand binding (aldosterone or cortisol in certain tissues), MRs translocate to the nucleus, upregulating ENaC (epithelial sodium channels) and Na+/K+-ATPase transcription in renal collecting ducts → *unrestrained sodium retention*.
- Concurrent non-genomic pathways activate PKC/MAPK cascades within minutes, exacerbating endothelial dysfunction via reactive oxygen species (ROS) overproduction.

**2. Pathophysiological Domino Effect:**
- **Volume Overload:** Plasma hypertonicity triggers ADH release → *aquaporin-2-mediated water reabsorption* → hypertension + edema.
- **Hypokalemic Alkalosis:** Distal nephron potassium wasting creates an electrochemical gradient favoring proton secretion (H+-ATPase activation).
- **Pro-Fibrotic State:** MR stimulation in cardiomyocytes/fibroblasts increases PAI-1/TGF-β → *myocardial stiffness* and diastolic dysfunction.

**3. Cortisol Crossover Chaos:**
In tissues expressing 11β-HSD2 (e.g., kidney), cortisol is normally oxidized to cortisone to prevent MR activation. However:
- Enzyme deficiency (*Apparent Mineralocorticoid Excess Syndrome*)
- Pharmacologic 11β-HSD inhibition (glycyrrhetinic acid in licorice)
...allow cortisol to flood MRs like aldosterone, inducing pseudohyperaldosteronism.

**4. Therapeutic Floodgate Control:**
Pharmacologic blockade strategies include:
- **Competitive Antagonists:** Spironolactone/eplerenone reduce mortality in HFrEF by attenuating adverse remodeling.
- **Aldosterone Synthase Inhibitors:** Baxdrostat targets CYP11B2 specifically for resistant hypertension without affecting glucocorticoids.
- **Dietary Sodium Restriction:** <2g/day mitigates pressure-natriuresis escape phenomena seen during chronic MR activation.

This deluge of receptor activity underscores why evolutionary conserved mechanisms tightly regulate aldosterone secretion via RAAS feedback loops—failure precipitates a torrent of cardiorenal pathology requiring targeted intervention at multiple levels. Would you like deeper explication on any particular facet?
when the floodgates open on the mr receptors

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