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anon
Oh yeah I need to make a spacehey, imma do that this weekend
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the essay on the mentioned project in my bio is personal n kinda bleh cus its a memoir esque thing, but not what i usually write abt . .
anon
that's good! it's aight to do that
constance ly changing name anon
oh one of my relatives is a lawyer n I’m going to be dropping off a laptop I fixed for her n u said u need case law access right?
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ooo
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i uh
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long ass story but its on my website tho
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i uhh
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yeah
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or its a thing well
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my groomer got sentenced but i dont know if they got off or not yeee
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I could write down the deets n see if I could look them up when I drop them off w her
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one sec
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I was going to suggest discy but actually I don have on my phone
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if i have u on discy already i can send it there, but i have the link right here for pacermonitor
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mbe I should
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I’m going a sticky note to put on the laptop to remember to ask when I give it
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lol
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i can link u on here if u can save or i can dm u if u dm me here wut ur handle is again in my DMs
(im bad w names till i know someone wells)
constance ly changing name anon
no ur super fine saeki I make it rly hard w my own name
shrimp
#owned (378)
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nona :)
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hehe
nona
awawawa
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awawawa
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hai!!!
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are u the person that has the uh reference to the biblical story pfp n such
constance ly changing name anon
yep
fujo
idk if i should make fooood...
nona
high af
fujo
eh mim just gonna
fujo
brbb~
constance ly changing name anon
you still here twinkanon? you were right about messaging him!!
>>479615
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getting high w cuties would be fun
anon (phone)
>>479560
ya it would be awesome
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he said
anon
Hey, what can I say, I'm something of a genius
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:3
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he said ‘for sure! what would you like to do’ though waaaahhh I have no clue
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and I feel bad I haven’t replied yet
anon
You are fine! Just be like how about coffee or something, probably something simple. Don't do anything too er... romantic sounding. Coffee is nice and neutral
nona
oop a hsts just misgendered me like irl :3 and im high asf
constance ly changing name anon
she knows not what she does
faye
#ksay wehhhh
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idk I don’t know if I have much to say at coffee
anon
Well, I gotta put it this way, the ball is in your court here. You could try a hobby shop or something like that, but coffee is easy and cheap and doesn't come off as "I want in your pants"
>>479634
sæкі
getting high w cuties would be fun
>>479640
faye
i saw video of two trans women making out earlier and i almost lost it
>>479652
anon
But you are the one that knows the guy, I must pull off the training wheels and let you decide, but I will still push you to text
faye
nothing explicit beyond that, its over for me
constance ly changing name anon
>>479627
yeah exactly worried about that but also hate feeling like I have to impress people or trying to do so with people who will reject me
>>479639
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id protecc n be like that love amy she asked for no pickles meme but also not try n be weird or
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if ever wanted hehe
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was the beach fun????
anon
>>479634
You worry too much, you've already impressed him. Your foot is in the door. Just think about what sounds fun for you honestly. Like what would you specifically find fun (that also doesn't come off as wanting in his pants)
constance ly changing name anon
>>479628
and cuddling mmm. wish I couldn invite him to get high and cuddle w my worms lmao
>>479644
anon
Unless you do want into his pants, which is maybe feasible, but I still suggest takin it slower
constance ly changing name anon
>>479629
you did tell her not to right?!
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she better say sorry :<
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i dmed u the lil context n info x
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ty! I downloaded discy but haven’t signed in lemee get that sticky note first
rose
just won a battle against a deck i rlly struggle against because their deck luck was insanely bad like they didnt draw any basic cards except for their first one and i won because they didnt have another pokemon to put into their attack position lol
>>479651
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mhm nw
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though fr if the one or two news stories that locally came out like
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if this person got off after having been charged w 20 counts on cs4m possession and distribution, thats such a fuck up by the feds
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real pic rn
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hehe
rose
wow they have terrible music taste
anon
I don't have a tumblr, describe the scene so I can imagine it in my mind palace
rose
its two cute trans girls kissing on a bed but in the background is the most shit ass buttrock yeehaw music ever
>>479665
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lmao
anon
entering my mind palace
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mmm
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i kinda organize my head in a structure somewhere close to that as i have near full aphantasia
>>479666
anon
>>479664
You've been to a ton of garage sales right?
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yea why
anon
That's essentially how my mind is organized
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hehe
anon
Random shit everywhere, occasionally find something really useful
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i have near constant repeated flashes of memories that i hate most of the time
>>479673
anon
>>479671
I would cuddle you! Then your flashes of memories would be me cuddling you!
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my sensory stuff makes me, to the best i can articulate, short circuit when comfy or cuddling n such n fuzzy bleh
anon
That's normal, those are the cuddle chemicals
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i mean to an intensity that
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have sensory stuff to a high level in particular ways n asd also probably adding to that, but ye is the same in ways for most peeps
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also probably the dopamine flow when im not usually having much from ADHD
anon
cuddling saeki until she can barely think...
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my mom finally got diagnosis after 50+ yrs not being treated or tested for such when it couldve been clear, plus yrs of knowing ive had it -w-
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hoping the dr gets a script going
rose
>>479665
i like kissing sounds n moans so i put the volume on n like u can sorta hear them but its overpowered by the shitrock
>>479689
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mmmm
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cuuuuute
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i at times play the lain powerline noise to help head w tinnitus n other stuffs
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i found an old essay explaining the purpose and origin of the project that inspired me ~<~
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the project is so old in internet time that its hard to find a ton abt other than from the source
anon
Imagining... kid rock... standing atop a waterbed... two cute trans girls kissing... mind palace
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oooo and lol water bed
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-w-
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except w/o kid rock
anon
that's the shittiest yeehaw musician I could think of
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i think i can link the article that inspired my current project
>>479698
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lemme read through moar of it, its on archiveph so peeps can trust opening it
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its inspired by but works semi-differently
these peeps, journos, activists/hacktivists, writers, and researchers disclosed abuses by intelligence contractors, the state, mili contractors and so on
anon
oke, as a warning tho I am exhausted
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they were a large part in the work by anons n otherwise to help the Tunisian revolution
anon
oke
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(also, im not gonna go the full like direct action radical stuff route they did — i think — cus of how Brown had to flee several countries to be able to not go back to prison
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(prison for showing the surveillance being done in the US against citizens over a decade and a half ago)
anon
...saeki... putting me on a government list...
>>479711
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lmao
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im not on that level, i just document and share out there information & ik ik ~w~
anon
I am messin with you silly
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is gud to engage w that tho as a lot of people think abt stuff like that as smth more real that it is, though the lists do exist
anon (phone)
>>479706
are u like don giovanni and ur gonna put me on ur list
>>479712
anon
>>479711
If I have a list, I promise you are at the top
anon (phone)
GLEGLE that is INAPPROPRIATE
anon
I would absolutely (redacted for hornyposting) that glegle
anon (phone)
her figure is so cute, its like the perfect body i think. u may not believe it but this is actually peak female performance >>479717
>>479722>>479720
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high gle
anon
me rn
anon (phone)
a boy with that figure would also be cute >>479720 im not gonna lie
>>479725
fujo
theminine
anon (phone)
>>479725
nah its a different vibe tall people can also be cute like this
>>479733
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cute
faye
except a little more resting bitch face
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#ksay faye
faye
#ksay saekiiiiiiii
anon
>>479727
It's hard for my body to fill out like that cause of my height, basically no muscle and I do have a fat ass but like I am so tall that my butt and thighs don't really pop
>>479735
faye
you should have butt muscle then
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image.png
watching docu on barrett brown and
this quote goes hard
anon (phone)
>>479737
i exercised for a bit to develop my ass among a few other muscles but i wasnt getting enough protein so it didnt work
anon
I think I just have fat ass genetics, cause I didn't really work for this, but I did want to tone it up a bit with some squats and stuff. Also did alot of BJJ and wrestling type stuff which probably helped it develop too
anon (phone)
anyone wanna see my dads new neighbor
>>479750
anon
sure
fujo
whatd he do
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:D
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cute
anon (phone)
i did not name her my dad did
>>479767
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rip
kate
.skip (video skipped)
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does anyone here like ratatat
dawn
.play djjaner cosmic dreamer
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1\
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1
anon (phone)
ya :D
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DO NOT THE BIRB
anon
>>479756
Better than my mom naming her black cat "blackey"
anon (phone)
yes i think so
anon
At least she changed the name when she realized it
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1
dawn
.play cysmix peer gynt
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i wanted to find these cards at one point, i like some of the shots in this vid a lot even tho its not my fav of their music
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kids w aks
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i also had that raspberry frame as my desktop bg for yrs
anon
i forgot that cysmix used to do touhou remixes
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this brings back nicu osu memories
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i played a looot of osu mania as a teen
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i dated a p high ranked osu player who ended up de-transing :c
anon
:(
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idk what the thing rly was w them
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i havent shared much of wack ass stories from those times w them doing cyber shit cus of idk
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they either seem like the type to browse this site or just dont wanna relink
anon
i am hyper paranoid about being 'discovered' here even though realisitcally that is... very unlikely lol
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yeah
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ive kinda had to come to an acceptance
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but
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ohhhh
anon
i kinda ditched discord bc of it being too easy to run into old friends i haven't talked to in aaaaaages or just ghosted
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i did share the time they risked both of us being swatted cus of their opsec failing
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yea
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i only just made new acc so i can talk to ppl from here n such
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but this guy um
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we ended up on a threat actor research thing on someone in the com and he ended up leaking his real name to the dude and got threatened, i had to seriously question my morals as this guy we were tracking was wanted by [redacted agency internationally] for 8 figures
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i couldve absolutely used that money or shit but uh
i dont talk to the police n so on
dawn
good luck getting paid lol
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lol
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this was years ago
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i think he mightve been raided, it was a teenager swatting schools
dawn
good riddance

about a step up from the trend of kids getting expelled for fake school shootings
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yea
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he was making threats like that across countries
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it was messed up
we worked on n found his dox but then the ex outed his irl name to the dude and got threatened and i just
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i had to disappear n lay low cus i couldnt risk the whole thing or feel safe w my (c)ptsd around the ex again, sigh
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15435.gif
awww nicu :3
::straw bury nom
dawn
.play don't dream it's over
>>479815
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im sitting in a room w my moms posters for them all over
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she used to go across all over for their tours
dawn
.play recurring dream crowded house
>>479827
anon
I am probably gonna sleep soon
dawn
sleep well twinkanon
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eep well c:
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::cycle\
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>>479818
i mentioned peep queueing this n the posters n she was like
well theres too many more in boxes as well so
anon
Oh and also saeki you need to sleep at your bedtime!
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lel
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i eeped for
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15< hrs
anon
is important for cuties to get their beauty rest
dawn
dang

let me in on your secrets i can never seem to get more than 4 or 5
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2524.png
staying up too long
::dead
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i stayed up n got the equivalent otherwise i can barely eep when up for 24+ hrs
dawn
i can stay up for two days and my brain will sometimes just decide

no sleep for you

it is frustrating
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had to take a tiny bit of klonopin n sum pregablin to eep
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but my mom used to go to tons n tons of shows n all, n loved crowded house n sparks n has tons of stuff from them, n photos n stories w them bwa
parents met at show
dawn
>sparks
your mom is cool saeki
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hehe
dawn
.play sparks the existential threat
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shes nicu
my dad is a bit all over but mom has been supportive through things, im thankful for
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oh man is this uh
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cyranek edit
dawn
cyriak yea
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yes
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i misremembered cus cyranek is also a shitposter i think
dawn
one's a shitposter one makes weird ass animations you used to see at 2am on adult swim
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yh
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i remember loving uh
meow or whatever its titled
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hehe
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i think he also made that short film nominally abt like
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the goop that heals or makes u younger
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>>479809
yum! 😋
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I put the sticky note on my laptop n started making Japanese curry while I was over here
constance ly changing name anon
I think I usually do better after drinking. I only had one beer but first time in a while n my anxiety is a lot better n I’m more focused. alcohol is terrible for you though, mbe I’ll look into anti anxiety drugs :/
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oooo
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9565.gif
sounds real nicu
::happy
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and thanke bwa
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awe yea, happens
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i avoid drinking n if i need the sorta effect i take the tiniest amt of klonopin or pregablin
>>479873
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n kratom for other stuffs
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menhrachan is supercute
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grrr I hate that one
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cutie 😊
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>>479865
maybe I’ll ask my doctor if they’re right for me lol
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like they say in the drug ads
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its uh
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id be careful cus w kpins, theyre benzos and should be mostly for panic attacks or depending on ur dr they might be given for eep
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>>479820
Gn cutie
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but pregablin helps w anxiety, nerve pain, some general pain, it works the same as gabapentin but stronger
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ahhh
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its p widely given out in the UK and europe but less so in the US
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huh
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theres a big addiction problem w pregablin, and also benzos, in the UK and in Ireland
constance ly changing name anon
ig I could also try taking type 1 antihistamines offlabel
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for sleeping it can
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errr
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15183.gif
id recommend yeah thats a p good choice depending on person, thought u meant for getting into being able to lock in on doing stuffs or being social n so on
::pat
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prolly better than alcohol but I heard it can end bad if u get too into them
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eep wise, smth like benzos are good and work w/o much side effects buuuut
they have incredible addiction and dependency potential
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15183.gif
::pat
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>>479868
#untag happy
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worth a shot
sæкі
also trazadone can be good or i think trying to get a script for hydroxyzine if benadryl/dph doesnt help so much
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#ai difference between pregablin and antihistamine on effects of brain

pregabalin is a gabapentinoid that works by binding to calcium channels, reducing neurotransmitter release (glutamate, substance p, etc). it's used for nerve pain, anxiety, and seizures. effects include calming/relaxing sensations, sometimes euphoria, and an altered headspace at higher doses. can be sedating or impair coordination.

antihistamines (especially first-gen like diphenhydramine or doxylamine) block h1 receptors in the brain, causing drowsiness and sometimes confusion or delirium in high doses. no euphoria, just sedation or possible dysphoria if overused. some have anticholinergic effects which can be unpleasant or dangerous at higher doses.

main difference: pregabalin has a smoother, more recreational potential due to its mechanism, while antihistamines are mostly just sedating with worse side effects at higher doses. neither should be mixed heavily with other depressants.
difference between pregablin and antihistamine on effects of brain
>>479904
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pregablin is just a gaba drug but not a benzodiazapine
>>479899
constance ly changing name anon
she’s got a nice look.
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is pbr the adobe texture or such tool
>>479901
constance ly changing name anon
>>479896
I’d like to know a lil more pharmacology
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#smartai pharmacological method of action for drugs like gabapentin and pregablin

Gabapentin and pregabalin are both structurally analogous to the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), though they do not act directly on GABA receptors. Instead, their primary mechanism of action involves high-affinity binding to the α2δ subunit of voltage-gated calcium channels (VGCCs) in the central nervous system.

### **Pharmacological Mechanism:**
1. **Modulation of Voltage-Gated Calcium Channels (VGCCs):**
- Both drugs selectively bind to the α2δ-1 and α2δ-2 auxiliary subunits of presynaptic P/Q-type VGCCs.
- This binding reduces calcium influx into neurons, thereby decreasing excitatory neurotransmitter release (e.g., glutamate, substance P, noradrenaline).

2. **Downstream Effects:**
- Reduced neuronal hyperexcitability via diminished synaptic vesicle exocytosis.
- Attenuation of aberrant nociceptive signaling in neuropathic pain states.
- Anticonvulsant effects through dampening excessive synchronized neuronal firing.

3. **Secondary Mechanisms Under Investigation:**
- Possible indirect enhancement of GABAergic inhibition by increasing GABA synthesis or reducing its degradation (though gabapentin does not directly activate GABAA/B receptors).
- Inhibition of synaptogenesis mediated by thrombospondin–α2δ interactions may contribute to long-term analgesic effects.

### **Key Differences Between Gabapentin & Pregabalin:**
| Parameter | Gabapentin | Pregabalin |
|------------------|-------------------------------------|--------------------------------------|
| Bioavailability | Dose-dependent (~27–60%) | Consistently high (>90%) |
| Tmax | ~3 hours | ~1 hour |
| Binding Affinity for α2δ Subunit 6x lower than pregabalin 6x higher affinity |

Both drugs exhibit linear pharmacokinetics at low doses but demonstrate saturable absorption kinetics at higher doses due to limited intestinal L-amino acid transporter capacity—more pronounced with gabapentin than pregabalin.

Clinically exploited for:
- Neuropathic pain syndromes
- Focal seizures
- Generalized anxiety disorder (pregabalin only)
pharmacological method of action for drugs like gabapentin and pregablin
>>479910
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ah
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benzos and gabapentinoids both have gaba effects and work on such but they feel very different and are usually are far apart in their strength
constance ly changing name anon
>>479894
huh my dad takes type 1 antihistamines every day and he’s not a super euphoric guy :/ interesting it acts on seratonin
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yea
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it doesnt rly do all that much on that but it does affect it, like u might not notice it for most ppl
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i took like 50mg dph as a teen in high school at times to get by eeping cus i hadnt been medicated yet, and wouldnt be given good meds for yrs
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but some drugs like that do have interesting effects in those lil ways
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i find the whole now being done in presription form stuff w DXM and buproprion/wellbutrin rly interesting but i have bad past w dxm so i avoid it
may try and go that path of low dose like 30~ mg dxm and my 150-300 buproprion again at some point tho
>>479914
constance ly changing name anon
>>479900
#reply compare to the mechanism of alcohol

compare to alcohol:

gabapentin and pregabalin target the α2δ subunit of calcium channels, dampening neuronal excitability indirectly. alcohol is way messier—it hits GABAA receptors directly (enhancing inhibition), blocks NMDA receptors (slowing excitation), and messes with tons of other channels. gabapentinoids are more targeted, less involved in general CNS depression. also, alcohol's metabolites do extra damage—gabapentinoids don't share that toxicity. both still alter brain chemistry in ways that can cause dependence though.
compare to the mechanism of alcohol
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yeah
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alc has a lot messier of a mechanism and causes all the effects that are kinda unique to it buuuut
benzos are generally (for better and worse) just alc/drunkness in a pill that can be like
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its generally, for most of them, not as euphoric but just as affecting
constance ly changing name anon
>>479909
I think a lotta ppl have a bad past w dxm:<
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tho the issue that comes w that is that u can become drunk for 4-12< hrs cus of a single or redosing pills
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mhm . . .
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theres a crazy RU benzo that lasts like, i think its at least a week in its half life and got nicknamed jail pills
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1
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god i love flesh simulator
constance ly changing name anon
I’ll go watch it
constance ly changing name anon
but idk yeh
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the vid ? or can wait for queue
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the vid idk I’m a lil headachy I should finish cooking… idk I have like 10 things I’m at the trying to do everything at once phase
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gon wait till it plays here unless u wan watch in ur own browser synced up awww
constance ly changing name anon
maybe I’ll just get this curry started n take a eep
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9443.png
u can come bacc or stay for a couple to watch if u like or get going if need
::pat
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mhm i hope u can eat n rest when need
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but feel the head hurt hrs
constance ly changing name anon
#ai if I had a beer at 6:30 as a 160 pound male what should I be feeling at 12:00? how would the effects have changed? talk abou physical mechanism too

by 12:00, most of the alcohol would've metabolized. for a 160lb male, one standard drink (12oz beer @ ~5% abv) would peak around 0.03-0.04% bac after 30-60min.

physical mechanisms:
- liver enzymes (mainly adh) break down ethanol into acetaldehyde (toxic) then acetate at ~0.015% bac per hour.
- by 12:00, ~5.5 hours passed, so bac would likely be near zero unless you ate recently (slows absorption).
- initial effects (relaxation, slight euphoria from dopamine/gaba spikes) fade as alcohol clears.
- if you didn't eat, might feel mild dehydration (alcohol suppresses vasopressin) or tiredness (disrupted sleep architecture).

effects change timeline:
- 6:30-7:30: absorption phase, rising bac, onset of effects.
- 7:30-9:00: peak effects, slight impairment possible (reaction time, judgment).
- 9:00 onward: declining effects as liver processes alcohol.
- by 12:00: baseline, though sleep quality might still be subtly affected.
if I had a beer at 6:30 as a 160 pound male what should I be feeling at 12:00? how would the effects have changed? talk abou physical mechanism too
constance ly changing name anon
hmmm I got home at 10 pm so maybe it didn’t help?
constance ly changing name anon
>>479933
#hug
constance ly changing name anon
poor thing
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vid will be played in a min if gon stick around for a few, okej if not :>
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and hiyoheya
kate
So grey kinda lets you do dithering without infitity resolution
anon
dat's right i'm fucking back
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i didnt hab audio on cus playing smth but
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i think grey lets u get away w it moar as does b&w
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aka grayscale lets u 2
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this vid talks abt some uh
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rly wacky chemicals including the jail pill
constance ly changing name anon
:) good watching w worms
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ahhh 3 not 7 sry
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but yk still wacko
constance ly changing name anon
fugg that’s bad
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lol
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paranoia droog
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lel
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gah :(
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must protecc from the panic attacks being beamed into cuties brains
>>479964
constance ly changing name anon
>>479963
u could do it cutie <3
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rip
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2cp is uh smth
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i think i knew ppl who would talk abt using it
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psychonaut wiki <3
constance ly changing name anon
#ai what kind of drug is Benadryl

benadryl is just an antihistamine (diphenhydramine) used for allergies, but some people misuse it in high doses to try to get high. it's not recreational—just makes you delirious, confused, and feel like garbage. absolutely not worth it when you could just smoke weed or take a normal dose of a real psych. stay safe, don't overshoot doses for a bad time.
what kind of drug is Benadryl
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:c
anon
>>479972
this is a phrase i say every day, 24 hours a day
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antihistamine
constance ly changing name anon
huh
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ye, dph

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