this brings back nicu osu memories

i played a looot of osu mania as a teen

i dated a p high ranked osu player who ended up de-transing :c

idk what the thing rly was w them

i havent shared much of wack ass stories from those times w them doing cyber shit cus of idk

they either seem like the type to browse this site or just dont wanna relink

yeah

ive kinda had to come to an acceptance

but

ohhhh

i did share the time they risked both of us being swatted cus of their opsec failing

yea

i only just made new acc so i can talk to ppl from here n such

but this guy um

we ended up on a threat actor research thing on someone in the com and he ended up leaking his real name to the dude and got threatened, i had to seriously question my morals as this guy we were tracking was wanted by [redacted agency internationally] for 8 figures

i couldve absolutely used that money or shit but uh
i dont talk to the police n so on

lol

this was years ago

i think he mightve been raided, it was a teenager swatting schools

yea

he was making threats like that across countries

it was messed up
we worked on n found his dox but then the ex outed his irl name to the dude and got threatened and i just

i had to disappear n lay low cus i couldnt risk the whole thing or feel safe w my (c)ptsd around the ex again, sigh

>>479813
awww

im sitting in a room w my moms posters for them all over

she used to go across all over for their tours

eep well c:

::cycle\

>>479818
i mentioned peep queueing this n the posters n she was like
well theres too many more in boxes as well so

lel

i eeped for

15< hrs

i stayed up n got the equivalent otherwise i can barely eep when up for 24+ hrs

had to take a tiny bit of klonopin n sum pregablin to eep

but my mom used to go to tons n tons of shows n all, n loved crowded house n sparks n has tons of stuff from them, n photos n stories w them bwa
parents met at show

hehe

shes nicu
my dad is a bit all over but mom has been supportive through things, im thankful for

oh man is this uh

cyranek edit

yes

i misremembered cus cyranek is also a shitposter i think

yh

i remember loving uh
meow or whatever its titled

hehe

i think he also made that short film nominally abt like

the goop that heals or makes u younger

oooo

and thanke bwa

awe yea, happens

i avoid drinking n if i need the sorta effect i take the tiniest amt of klonopin or pregablin

n kratom for other stuffs

its uh

id be careful cus w kpins, theyre benzos and should be mostly for panic attacks or depending on ur dr they might be given for eep

but pregablin helps w anxiety, nerve pain, some general pain, it works the same as gabapentin but stronger

its p widely given out in the UK and europe but less so in the US

theres a big addiction problem w pregablin, and also benzos, in the UK and in Ireland

for sleeping it can

errr

eep wise, smth like benzos are good and work w/o much side effects buuuut
they have incredible addiction and dependency potential

also trazadone can be good or i think trying to get a script for hydroxyzine if benadryl/dph doesnt help so much

.play [YouTube]

pregablin is just a gaba drug but not a benzodiazapine

is pbr the adobe texture or such tool

#smartai pharmacological method of action for drugs like gabapentin and pregablin

Gabapentin and pregabalin are both structurally analogous to the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), though they do not act directly on GABA receptors. Instead, their primary mechanism of action involves high-affinity binding to the α2δ subunit of voltage-gated calcium channels (VGCCs) in the central nervous system.

### **Pharmacological Mechanism:**
1. **Modulation of Voltage-Gated Calcium Channels (VGCCs):**
- Both drugs selectively bind to the α2δ-1 and α2δ-2 auxiliary subunits of presynaptic P/Q-type VGCCs.
- This binding reduces calcium influx into neurons, thereby decreasing excitatory neurotransmitter release (e.g., glutamate, substance P, noradrenaline).

2. **Downstream Effects:**
- Reduced neuronal hyperexcitability via diminished synaptic vesicle exocytosis.
- Attenuation of aberrant nociceptive signaling in neuropathic pain states.
- Anticonvulsant effects through dampening excessive synchronized neuronal firing.

3. **Secondary Mechanisms Under Investigation:**
- Possible indirect enhancement of GABAergic inhibition by increasing GABA synthesis or reducing its degradation (though gabapentin does not directly activate GABAA/B receptors).
- Inhibition of synaptogenesis mediated by thrombospondin–α2δ interactions may contribute to long-term analgesic effects.

### **Key Differences Between Gabapentin & Pregabalin:**
| Parameter | Gabapentin | Pregabalin |
|------------------|-------------------------------------|--------------------------------------|
| Bioavailability | Dose-dependent (~27–60%) | Consistently high (>90%) |
| Tmax | ~3 hours | ~1 hour |
| Binding Affinity for α2δ Subunit 6x lower than pregabalin 6x higher affinity |

Both drugs exhibit linear pharmacokinetics at low doses but demonstrate saturable absorption kinetics at higher doses due to limited intestinal L-amino acid transporter capacity—more pronounced with gabapentin than pregabalin.

Clinically exploited for:
- Neuropathic pain syndromes
- Focal seizures
- Generalized anxiety disorder (pregabalin only) pharmacological method of action for drugs like gabapentin and pregablin

>>479898
[Wikipedia]

ah

benzos and gabapentinoids both have gaba effects and work on such but they feel very different and are usually are far apart in their strength

yea

it doesnt rly do all that much on that but it does affect it, like u might not notice it for most ppl

i took like 50mg dph as a teen in high school at times to get by eeping cus i hadnt been medicated yet, and wouldnt be given good meds for yrs

but some drugs like that do have interesting effects in those lil ways

i find the whole now being done in presription form stuff w DXM and buproprion/wellbutrin rly interesting but i have bad past w dxm so i avoid it
may try and go that path of low dose like 30~ mg dxm and my 150-300 buproprion again at some point tho

yeah

alc has a lot messier of a mechanism and causes all the effects that are kinda unique to it buuuut
benzos are generally (for better and worse) just alc/drunkness in a pill that can be like

its generally, for most of them, not as euphoric but just as affecting

tho the issue that comes w that is that u can become drunk for 4-12< hrs cus of a single or redosing pills

mhm . . .

theres a crazy RU benzo that lasts like, i think its at least a week in its half life and got nicknamed jail pills

.search flesh simulator scariest worst drugs

1. 1.
   
   Top 6 Most Horrifying Molecules | FLESH SIMULATOR

   FLESH SIMULATOR

   7:15
2. 2.
   
   Reddit is a Psy-Op | FLESH SIMULATOR

   FLESH SIMULATOR

   8:13
3. 3.
   
   The redditor who boofed yeast to stay drunk 24/7

   FLESH SIMULATOR

   3:12
4. 4.
   
   DRUGS EATING THE BODY. KENSINGTON AVE PHILADELPHIA

   ALL TIME MEDIA

   0:11
5. 5.
   
   A Quick One Regarding an Evildoer | FLESH SIMULATOR

   FLESH SIMULATOR

   3:33

1

god i love flesh simulator

the vid ? or can wait for queue

gon wait till it plays here unless u wan watch in ur own browser synced up awww

mhm i hope u can eat n rest when need

but feel the head hurt hrs

vid will be played in a min if gon stick around for a few, okej if not :>

and hiyoheya

So grey kinda lets you do dithering without infitity resolution

i didnt hab audio on cus playing smth but

i think grey lets u get away w it moar as does b&w

aka grayscale lets u 2

this vid talks abt some uh

rly wacky chemicals including the jail pill

ahhh 3 not 7 sry

but yk still wacko

lol

paranoia droog

lel

must protecc from the panic attacks being beamed into cuties brains

rip

2cp is uh smth

i think i knew ppl who would talk abt using it

psychonaut wiki <3

:c

antihistamine

ye, dph

.play flesh simulator whats up with dcs most famous pizza place

flesh is based leftist to ansynd

or libertarian socialist

>>479982
#smooch

he doesnt rly use the terms but used the term to describe how he aligns in a video addressing palestine, as his fans include weirdo chuds cus of his style

he did a pod w a tiny show duo of trans peeps w one commie and one anarchist and talked abt movies

>>479986
yeah

i write in such different ways depending on what its for that other than my style i think it could do that, plus being trans

he did an amazing documentary on the time that this group of child abusers n serial killers were covered up by the US gov and burned the filing cabinet of cards w customers information
(likely cus it had state and famous ppl on them)

that can bring a lot of aaa stuff tho when i was like idk 18 or so i did similar until i came out n then came out again

i did write political esc theory style essays that were closer to what i am now tho before knowing where i stood on things

but i did moderate, then co own, a server w 3-4k members that had ppl saying slurs, mostly idiot channer kids
when i was like 16-19 (and then got banned cus the other co owned got pissed tf off n screamed at me on call for half n hour while i cried, fucking asshole)

(tho i did do smth dumdum, i was 19 and i found out he was being incredibly toxic n hiding a relationship w the other co owner the whole time, it was probably in his best interest to get me outta there)

>>479999
>boop

>>480000
yea i just dont use social platforms generally beyond chatrooms like this, but i did make a discy again n spacehey for my writing pen name *ahem* as it is here

one of my fav video essay esc reviewer peeps community had me warned one time for saying the word vidya

and i found out they warned and had rules against anything considered chan language and including anything derived from pepe

i was a patron of the guys for like a yr

lel

i didnt get banned but i stopped going there a ton, though the guy does have a ton and memes abt how most of his audience most dedicated to him is trans

he also put a single frame in a video that showed he donated, i think it was, 26000 dollars to the trevor project after he got 260 dollars of free game codes from CDPR

>>480011
yeah

i dont disagree w that one in a community like that one, cus of the co-opting and then later creator killing him off n so on, but its still notable

i have a few peeps ive supported on places over the yrs but he apparently took health n recover leave for two yrs and came back the other month

(is tim rogers/action button, of the up to 12 hr video game review fame)

and yeah thats an understandable reason

though i do need to continue the 10 hr, practically a TV show, he put out on LA Noir recently

i was there for the premiere he did one day randomly after 2+ yrs of silence other than twitch

>>480023
yeah i get the attempt and thought behind it but it just leads to so much stress for me as a person

i have like

my OCD and PTSD issues cause me to way over-stress abt things like warnings or bans at times in community spaces

[YouTube]
this is rly sick tho

ima continue it

seeing him, as a very straightedge punk type dood, smoking fake cigarettes is very funny to me

and idk, i dont like being a bother to ppl unless i know that morally such places are clearly fucked

in that case i will at times use the uh diverse tactics i know for some reason to pain the fascist mod types

yea thasunderstandable

i like finding exploits n vulns for fun tho so being able to do that when its worthwhile n not gonna get me fucked in some way is fun

yea errr,i have too much of a need cus of OCD or who i am to not weigh on ppl to a fault

i end up not reaching out to things or ppl i need to guh

aw mhm

i havent answered the old friend . . .

i um

i used this chat site for yrs and found it in 2017 n

i quit cus of self isolating cus of bad mental state n working myself too hard around the election n

i need to get bacc on or add/talk to this fren who reached out after i added them, n see if i can find the adds for some of those from there

before i daily posted here, i would use that chat a lot of the time after i got way too liquid stress injected by my old disc account

all for a review of la noire

he also started the first episode of a patreon podcast that featured the mc voice/+actor from FF16

i dont anymore cus im brokie mainly, or rather i need to keep what i save to be able to wait till im working stably/have stable income again

yeah

i do that too

are yt peeps on there?

mhm

yeah

i mainly like

if i appreciate someones stuff n have stable income, ill support them how best gets them money a bit — like im not subbing on twitch or yt cus the cut is shit

yeah

i use it for uhhh
lewd stuff ig

idk if youtubers are on there much ik theres some vrc modellers n stuff but idk

awwww

>>480095
#smooch

nice to see chu agains

also like
i support places i know r doing gud work n struggling or so on

like researchers n journos who are putting themselves on the line for sharing stuff people need to know abt

but also i did it mainly

and

i mean like

https://www.404media.co/

lel

i get it

i mean independents that are leaking or sharing that ppl hacked shit

haiiii daveeee

saw dakota earlier n had short convo abt the medicaid trans ban

>>480112
also i found the post that shortly explains part of what inspired my current group/project

lemme link it one sec

>>480117
first two paragraphs
https://archive.ph/CPVzX

and its also good to recognize that there are plenty of ppl who are going to now newly be hurt even if banned in some states rn

its a big thing we shouldnt write off as a foregone conclusion or use the word 'just' w, i forget the word — along the lines of diminishing

hey

if they were to, theres always gonna be people locally and around the world n country that will provide it

and where u can be able to access, even if its a struggle

theyre rly hard to regulate and enforce/prevent

even T is hard for them to

>>480136
yeah

it sucks that the fed funded community medical centers have been hit as hard as they have tho.

rly sucks

thanks to peep here btw i might be getting access or details on if the person who groomed me got sentenced and to what

or if the fed fucked up their case and it got dropped or so on

ye

stock up w help of or sort of w ur dr if u can and through diy for those not applicable

i mean that started months ago

good interview that i believe gare davis did for it could happen here around march

but they are going to likely be hit harder to some extent

and all the local small hospitals getting closed rn

mhm...

:')))

depends on where n what u r but generally thats just the repression adding stress, tho u shouldnt hold back or be quiet per-emptively

yeah

thaskinda what i was getting at

if u stay silent now, u let it only get worse ~,~

that is a legitimate, understandable, valid worry but is smth you should do ur best to fight by connecting w others who can give you info when possible, & be there to help protecc in numbers as needed

>>480174
dont have to n can be done online/through comms in spaces online but does take time n work, find local online mutual aid communities or ones that can direct u to such when u can

dont have to go out or u can work w them to be able to do wh works for you

i use tor for most stuff thats at all journalistic work or research into stuff thats at all questionable, but then encrypted tools for otherwise

use cryptpad (an open source self hosted or hosted by computer/encryption privacy orgs) over google drive or such to host code, documents, slideshows, kanbans (trello like stuff) when possible

its free n encrypted w password protection for docs at your choice
and also https://pad.riseup.net/ for pastebin esc or document writing w group writing abilities, both of them have, hosted by trans/queer/autistic n so on anarchists