I've heard older stuff like boltzmann machines saw use in recommendation algorithms

#ai What are terms and concepts one would use to model the differentiation of stem cells when creating engineered tissue structures?

key terms and concepts for modeling stem cell differentiation in engineered tissues:

cell fate determination - how stem cells choose specific lineages
niche signaling - local microenvironment cues (chemical, mechanical, electrical)
morphogen gradients - concentration-dependent cell responses (Wnt, BMP, FGF)
transcriptional networks - core regulatory circuits (Oct4, Sox2, Nanog downregulation)
epigenetic regulation - chromatin remodeling, methylation patterns
cell-cell communication - juxtacrine/paracrine signaling (Notch, TGF-β)
biophysical cues - matrix stiffness, topography, shear stress
metabolic state shifts - glycolysis vs oxidative phosphorylation
feedback loops - balancing self-renewal vs differentiation
pattern formation - spatial organization principles (Turing models)
lineage tracing - tracking progeny of single cells What are terms and concepts one would use to model the differentiation of stem cells when creating engineered tissue structures?

Like. stuff where the answer isn't directly used to make consequential decisions

But instead just gives you another path to check

#ai Concepts used to model histone modifications and their effect on gene regulation:

chromatin states, markov models, hidden markov models (hmms), dynamical systems, bayesian networks, machine learning (deep learning, random forests), boolean networks, differential equations, monte carlo simulations, information theory metrics, graph theory. key chromatin marks like h3k4me3 (activation), h3k27me3 (repression), dna methylation often modeled as binary or continuous variables. some models integrate tf binding data or sequence features. shit gets complex real quick. Concepts used to model histone modifications and their effect on gene regulation:

Hmm. I'm not sure markov models show up there outright, it's probably bleeding ML concepts into there

>>496918
What in particular did you have in mind?

Ah, yeah

the hyperdimensional bit thing

>>496932
yeah

the whole thing of like. the "law of cosines" where the dot product of random vectors in superhighdimension spaces basically is 0 for anything that's not the same thing

which roughly corresponds to nigh-perpendicularness

3blue1brown has been doing a lot of cool videos on the underlying algorithms

as has welch labs and artem kirsanov

idk. channels like that are why i find it difficult to fully divest from spaces like youtube

>>496911
thread is roughly starting at this post or so

thread as in like. topic

microtopic. it's not "the thread's" topic but it's the topic that's being discussed now

the histone modification stuff is like. just me using that as an example to find more detailed information on a relatively niche concept that might not be well-answered with standard searching tools

im eating frenched fries

.play [YouTube]

i like your hair!

taking care of yourself is good!

mmm yea

>>497014
acab (assigned cop at birth)

nah this one is already long enough

oh i was talking about the music queue

in terms of donuts, i see, you need miles of donuts... like. a really big maple bar

i wonder if there's any actual limit to extruding and baking a very long maple bar provided you have sufficient feedstock material

well, extruding the dough, baking it, and glazing it...

i don't know. it sounds like you probably could set up a machine to do that for arbitrary length

hard time in the slammer (your stomach)

spaghetti is good!

cozi.

do any of you enjoy to bake

this is the yin and the yang, the baker and the baked goods enjoyer

like. i've tried marbling cookies before by mixing cocoa powder with a portion of the dough and artfully recombining them after but i think i didn't use enough cocoa powder to get the color to stick out. idk

ostensibly you use loads of solid-at-room-temperature-fat so that the dough partially "melts" when you bake it and spreads out, and that then is something you can tune to adjust the qualities of the cookie

what's with that weird picture that keeps showing up for that db query

.play [YouTube]

i really like zeroranger

oh, va-11halla has a lot of nice tracks too

i guess it's kind of strange because the ost for that is hand-picked by you the player and you don't know what events are going to happen beforehand

so it doesn't quite sync up with momentous events i guess. but the vibe is really nice

stylesheets are a really fun concept

i like the idea of being able to like. define something on my own computer and then every site i look at has that cool theming to it

mmmm

the opening cutscene of zeroranger is really coolly choreographed

hmm. maybe this is too much. i should probably drop it from the playlist since there's a lot of variations on the same tune

.skip (video skipped)

eh, i like valhalla

i really like the open-sounding pads here

i forget what this kind of vibe is called

vaguely vaporwave

but without the singing

tbh i feel like the singing distracts from it

though perhaps i also just have a vendetta against singing at all because i resent what happened to my own voice

idk. i value what constructed mechanisms can do over accidents of biology

oh this track is iconic

real..

i like the way the percussion sounds here

this melody seems somehow familiar to some other context

it's strangely boisterous

this reminds me of the sonic r ost

i guess it's trying to evoke the same era of "elevator music" vibes

idk ostensibly it's a corporate style of music production. stock music one would use in like. employee training videos even though i unironically think the music sounds cool even if it's used for stale contexts

have you ever been wrapped up in a blanket like a burrito

i can recommend this it's very cozy

heights of comfort of the humble worm

i like this track

this feels like something you'd hear in like. an 80s-90s anime opening

sollux could do so much better than eridan

i love the vibes of this bit of the track

the synth bass

i cease to be human and become physics

i'm not sure. does the capacity to feel love exist within me

notionally closeness sounds nice

if i think about myself in the context of another human being i think about how my body has been warped and i immediately dissociate

idk. i feel like i should never actually see a medical professional ever even for checkups or other maintenance care because insurance is probably going to ratfuck and then charge me a gazillion dollars

i don't even get what the point of medical insurance is they negotiate for absurdly high prices for anyone not in their cabal and then you basically can't actually ever get medical care one way or the other because you never actually get things covered

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